Structure of PDB 1n6p Chain A

Receptor sequence
>1n6pA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
ICQFKLVLLGESEVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDT
TVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKE
LQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTS
MNVNEIFMAIAKKL
3D structure
PDB1n6p High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-Binding Loop
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S34 T52 S17 T35
BS02 GNP A S29 E30 G32 K33 S34 S35 F45 H46 E47 Q49 S51 T52 G78 N133 K134 D136 L137 S163 A164 K165 S12 E13 G15 K16 S17 S18 F28 H29 E30 Q32 S34 T35 G61 N116 K117 D119 L120 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:1n6p, PDBe:1n6p, PDBj:1n6p
PDBsum1n6p
PubMed12433916
UniProtP20339|RAB5A_HUMAN Ras-related protein Rab-5A (Gene Name=RAB5A)

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