Structure of PDB 1n6h Chain A

Receptor sequence
>1n6hA (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
GNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCL
DDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNW
VKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSA
KTSMNVNEIFMAIAKKL
3D structure
PDB1n6h High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-Binding Loop
ChainA
Resolution1.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S34 T52 S20 T38
BS02 GNP A S29 A30 G32 K33 S34 S35 F45 H46 E47 Q49 S51 T52 G78 N133 K134 D136 L137 S163 A164 K165 S15 A16 G18 K19 S20 S21 F31 H32 E33 Q35 S37 T38 G64 N119 K120 D122 L123 S149 A150 K151
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:1n6h, PDBe:1n6h, PDBj:1n6h
PDBsum1n6h
PubMed12433916
UniProtP20339|RAB5A_HUMAN Ras-related protein Rab-5A (Gene Name=RAB5A)

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