Structure of PDB 1n52 Chain A

Receptor sequence
>1n52A (length=732) Species: 9606 (Homo sapiens) [Search protein sequence]
ETEDHLESLICKVGEKSACSLESNLEGLAGVLEADLPNYKSKILRLLCTV
ARLLPEKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNYNEAV
YLVRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDVPQVRRDWYVYAFLS
SLPWVGKELYEKKDAEMDRIFANTESYLKRRQKTHVPMLQVWTADKPHPQ
EEYLDCLWAQIQKLKKDRWQERHILRPYLAFDSILCEALQHNLPPFTPPP
HTEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCIIKSH
WKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTL
LIELCKLQPGSLPQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQ
FRWSWEDWSDCLSQDPESPKPKFVREVLEKCMRLSYHQRILDIVPPTFSA
LCPANPTCIYKYGDESSNSLPGHSVALCLAVAFKSKATNDEIFSILKDVP
NFNPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAESDEGKLHVL
RVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLFV
WEILHSTIRKMNKHVLKIQKELEEAKEKVLEEQIERLQEKVESAQSEQKN
LFLVIFQRFIMILTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQHHQII
QQYMVTLENLLFTAELDPHILAVFQQFCALQA
3D structure
PDB1n52 Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
ChainA
Resolution2.11 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A Y761 T764 Y703 T706
Gene Ontology
Molecular Function
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000245 spliceosomal complex assembly
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0002191 cap-dependent translational initiation
GO:0006370 7-methylguanosine mRNA capping
GO:0006401 RNA catabolic process
GO:0006406 mRNA export from nucleus
GO:0006408 snRNA export from nucleus
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0008334 histone mRNA metabolic process
GO:0008380 RNA splicing
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0030307 positive regulation of cell growth
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031053 primary miRNA processing
GO:0031124 mRNA 3'-end processing
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035195 miRNA-mediated post-transcriptional gene silencing
GO:0042789 mRNA transcription by RNA polymerase II
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0050684 regulation of mRNA processing
GO:0051028 mRNA transport
GO:0051607 defense response to virus
GO:1905216 positive regulation of RNA binding
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005846 nuclear cap binding complex
GO:0034518 RNA cap binding complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1n52, PDBe:1n52, PDBj:1n52
PDBsum1n52
PubMed12434151
UniProtQ09161|NCBP1_HUMAN Nuclear cap-binding protein subunit 1 (Gene Name=NCBP1)

[Back to BioLiP]