Structure of PDB 1n4h Chain A

Receptor sequence
>1n4hA (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREA
LWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRM
CRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEE
EIALFSSAVLISPDRAWLLEPRKVQKLQEKIYFALQHVIQKNHLDDETLA
KLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFN
3D structure
PDB1n4h All-trans retinoic acid is a ligand for the orphan nuclear receptor RORbeta
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K71 Q81 I85 K89 P237 L238 E241 K71 Q81 I85 K89 P237 L238 E241
BS02 REA A Q21 C55 V96 M100 A135 Q21 C55 V96 M100 A135 MOAD: Kd=280nM
PDBbind-CN: -logKd/Ki=6.55,Ki=0.28uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1n4h, PDBe:1n4h, PDBj:1n4h
PDBsum1n4h
PubMed12958591
UniProtP45446|RORB_RAT Nuclear receptor ROR-beta (Gene Name=Rorb)

[Back to BioLiP]