Structure of PDB 1n1y Chain A

Receptor sequence
>1n1yA (length=628) Species: 5698 (Trypanosoma rangeli) [Search protein sequence]
AASLAPGSSRVELFKRKNSTVPFEESNGTIRERVVHSFRIPTIVNVDGVM
VAIADARYETSFDNSFIETAVKYSVDDGATWNTQIAIKNSRASSVSRVMD
ATVIVKGNKLYILVGSFNKTRNSWTQHRDGSDWEPLLVVGEVTKSAANGK
TTATISWGKPVSLKPLFPAEFDGILTKEFVGGVGAAIVASNGNLVYPVQI
ADMGGRVFTKIMYSEDDGNTWKFAEGRSKFGCSEPAVLEWEGKLIINNRV
DGNRRLVYESSDMGKTWVEALGTLSHVWTNSPTSNQQDCQSSFVAVTIEG
KRVMLFTHPLNLKGRWMRDRLHLWMTDNQRIFDVGQISIGDENSGYSSVL
YKDDKLYSLHEINTNDVYSLVFVRLIGELQLMKSVVRTWKEEDNHLASIC
TPVVPAGCGAAVPTAGLVGFLSHSANGSVWEDVYRCVDANVANAERVPNG
LKFNGVGGGAVWPVARQGQTRRYQFANYRFTLVATVTIDELPKGTSPLLG
AGLEGPGDAKLLGLSYDKNRQWRPLYGAAPASPTGSWELHKKYHVVLTMA
DRQGSVYVDGQPLAGSGNTVVRGATLPDISHFYIGGPRSKGAPTDSRVTV
TNVVLYNRRLNSSEIRTLFLSQDMIGTD
3D structure
PDB1n1y The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A R39 D63 M99 D100 R318 Y346 R39 D63 M99 D100 R318 Y346
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1n1y, PDBe:1n1y, PDBj:1n1y
PDBsum1n1y
PubMed12507479
UniProtO44049

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