Structure of PDB 1n0t Chain A

Receptor sequence
>1n0tA (length=257) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW
WYDKGEC
3D structure
PDB1n0t Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AT1 A E13 Y61 P89 L90 T91 R96 G141 S142 T143 E193 Y220 E9 Y57 P85 L86 T87 R92 G137 S138 T139 E189 Y216 MOAD: ic50=12.2uM
PDBbind-CN: -logKd/Ki=4.91,IC50=12.2uM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1n0t, PDBe:1n0t, PDBj:1n0t
PDBsum1n0t
PubMed12519060
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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