Structure of PDB 1mzj Chain A

Receptor sequence

>1mzjA (length=334) Species: 140437 (Streptomyces sp. R1128)

GLRVPERRFSRVLGVGSYRPRREVSNKEVCTWIDSTEEWIETRTGIRSRR
IAEPDETIQVMGVAASRRALEHAGVDPAEIDLVVVSTMTNFVHTPPLSVA
IAHELGADNAGGFDLSAACAGFCHALSIAADAVESGGSRHVLVVATERMT
DVIDLADRSLSFLFGDGAGAAVVGPSDVPGIGPVVRGIDGTGLGSLHMSS
SWDQYVEDPSVGRPALVMDGKRVFRWAVADVVPAAREALEVAGLTVGDLV
AFVPHQANLRIIDVLVDRLGVPEHVVVSRDAEDTGNTSSASVALALDRLV
RSGAVPGGGPALMIGFGAGLSYAGQALLLPDPPS

3D structure

• PDB: 1mzj Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.180: beta-ketoacyl-[acyl-carrier-protein] synthase III.
  2.3.1.300: branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	A	S37 W41 R45 R160 F164 L165 F166 M220 G222 K223 F226 A259 N260 N288	S35 W39 R43 R158 F162 L163 F164 M218 G220 K221 F224 A257 N258 N286

Gene Ontology

Molecular Function

• GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity

Biological Process

• GO:0006633 fatty acid biosynthetic process
• GO:0044550 secondary metabolite biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1mzj, PDBe:1mzj, PDBj:1mzj
• PDBsum: 1mzj
• PubMed: 12429097
• UniProt: Q9F6D4|FABH_STRLI Beta-ketoacyl-[acyl-carrier-protein] synthase III (Gene Name=fabH)