Structure of PDB 1mxf Chain A

Receptor sequence
>1mxfA (length=247) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAAR
AGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPL
LPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGF
CVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEY
RRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA
3D structure
PDB1mxf Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R22 D169 Y182 K186
Catalytic site (residue number reindexed from 1) R12 D140 Y153 K157
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A R22 R43 H44 S45 L71 N101 S103 E131 L167 K186 P212 G213 S215 R12 R33 H34 S35 L61 N91 S93 E111 L138 K157 P183 G184 S186
BS02 MTX A R22 S103 Y105 Y182 P218 M221 Y229 R12 S93 Y95 Y153 P189 M192 Y200
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1mxf, PDBe:1mxf, PDBj:1mxf
PDBsum1mxf
PubMed16168672
UniProtQ8I814

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