Structure of PDB 1mvx Chain A

Receptor sequence
>1mvxA (length=269) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
KLDSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQ
YRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDA
QGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGV
RSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDAS
EYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQ
PLEELTFDYAGAKDFSPVQ
3D structure
PDB1mvx Structure of the SET domain histone lysine methyltransferase Clr4.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y357 Y451
Catalytic site (residue number reindexed from 1) Y165 Y259
Enzyme Commision number 2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.366: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C260 C307 C311 C68 C115 C119
BS02 ZN A C307 C313 C115 C121
BS03 ZN A C260 C268 C276 C68 C76 C84
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0042054 histone methyltransferase activity
GO:0046974 histone H3K9 methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:1mvx, PDBe:1mvx, PDBj:1mvx
PDBsum1mvx
PubMed12389037
UniProtO60016|CLR4_SCHPO Histone-lysine N-methyltransferase, H3 lysine-9 specific (Gene Name=clr4)

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