Structure of PDB 1muw Chain A

Receptor sequence

>1muwA (length=386) Species: 1963 (Streptomyces olivochromogenes)

SYQPTPEDRFTFGLWTVGWQGRDPFGDATRPALDPVETVQRLAELGAHGV
TFHDDDLIPFGSSDTERESHIKRFRQALDATGMTVPMATTNLFTHPVFKD
GGFTANDRDVRRYALRKTIRNIDLAVELGAKTYVAWGGREGAESGAAKDV
RVALDRMKEAFDLLGEYVTSQGYDIRFAIEPKPNEPRGDILLPTVGHALA
FIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQSG
IKYDQDLRFGAGDLRAAFWLVDLLESAGYEGPRHFDFKPPRTEDIDGVWA
SAAGCMRNYLILKERAAAFRADPEVQEALRASRLDELAQPTAADGVQELL
ADRTAFEDFDVDAAAARGMAFERLDQLAMDHLLGAR

3D structure

• PDB: 1muw Active Site Dynamics at 0.86A: Crystallographic Analysis of a Metal-Mediated Hydride Shift
• Chain: A
• Resolution: 0.86 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H53 D56 M87 E180 K182 E216 H219 D244 D254 D256 D286
• Catalytic site (residue number reindexed from 1): H53 D56 M87 E180 K182 E216 H219 D244 D254 D256 D286
• Enzyme Commision number: 5.3.1.5: xylose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	E216 H219 D254 D256	E216 H219 D254 D256
BS02	MN	A	E180 E216 D244 D286	E180 E216 D244 D286
BS03	MG	A	D162 E206 R207 Y211	D162 E206 R207 Y211
BS04	MG	A	P35 L57 H70	P35 L57 H70

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0009045 xylose isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0042732 D-xylose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1muw, PDBe:1muw, PDBj:1muw
• PDBsum: 1muw
• UniProt: P15587|XYLA_STROL Xylose isomerase (Gene Name=xylA)