Structure of PDB 1mt6 Chain A

Receptor sequence
>1mt6A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFK
GQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYG
KFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALL
PDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDS
RDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDM
FVHPRFGPIKCIRTLRAVEADEELTVAYGY
3D structure
PDB1mt6 The active site of the SET domain is constructed on a knot
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y245 H293 H297 Y305 Y335
Catalytic site (residue number reindexed from 1) Y188 H236 H240 Y248 Y278
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A A226 E228 N265 H293 K294 N296 H297 Y335 A169 E171 N208 H236 K237 N239 H240 Y278 BindingDB: IC50=30000nM
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0140945 histone H3K4 monomethyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005694 chromosome

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Cellular Component
External links
PDB RCSB:1mt6, PDBe:1mt6, PDBj:1mt6
PDBsum1mt6
PubMed12389038
UniProtQ8WTS6|SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (Gene Name=SETD7)

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