Structure of PDB 1ms6 Chain A

Receptor sequence
>1ms6A (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSA
QNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQ
YDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRS
GVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMAR
NKGNHCGIASFPSYPEI
3D structure
PDB1ms6 Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H164 N184
Catalytic site (residue number reindexed from 1) Q19 C25 H164 N184
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BLN A G23 C25 G68 G69 F70 M71 A140 F146 N163 G23 C25 G68 G69 F70 M71 A140 F146 N163 PDBbind-CN: -logKd/Ki=9.52,Kd=0.3nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ms6, PDBe:1ms6, PDBj:1ms6
PDBsum1ms6
PubMed12459015
UniProtP25774|CATS_HUMAN Cathepsin S (Gene Name=CTSS)

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