Structure of PDB 1mru Chain A

Receptor sequence
>1mruA (length=269) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSF
YLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAV
KVMDFGIARAITAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFT
GDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAA
EMRADLVRVHNGEPPEAPK
3D structure
PDB1mru Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156 T179
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154 T162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A L17 S23 V25 A38 K40 V95 M145 M155 D156 L15 S21 V23 A36 K38 V93 M143 M153 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1mru, PDBe:1mru, PDBj:1mru
PDBsum1mru
PubMed12548283
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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