Structure of PDB 1mrg Chain A

Receptor sequence
>1mrgA (length=246) Species: 3673 (Momordica charantia) [Search protein sequence]
DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLM
HLFNRDGKTITVAVDVTNIYIMGYLADTTSYFFNEPAAELASQYVFRDAR
RKITLPYSGDYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGA
LLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQ
LAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRNI
3D structure
PDB1mrg Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I71 E160 R163
Catalytic site (residue number reindexed from 1) I71 E160 R163
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A Y70 I71 G109 Y111 I155 E160 R163 Y70 I71 G109 Y111 I155 E160 R163
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030598 rRNA N-glycosylase activity
GO:0090729 toxin activity
Biological Process
GO:0006952 defense response
GO:0017148 negative regulation of translation
GO:0035821 modulation of process of another organism

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Molecular Function
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Biological Process
External links
PDB RCSB:1mrg, PDBe:1mrg, PDBj:1mrg
PDBsum1mrg
PubMed7619070
UniProtP16094|RIP1_MOMCH Ribosome-inactivating protein momordin I

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