Structure of PDB 1mqw Chain A

Receptor sequence
>1mqwA (length=200) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DFETISSETLHTGAIFALRRDQVRMPGGGIVTREVVEHFGAVAIVAMDDN
GNIPMVYQYRHTYGRRLWELPAGLLDVAGEPPHLTAARELREEVGLQAST
WQVLVDLDTAPGFSDESVRVYLATGLREVGRPEAHHEEADMTMGWYPIAE
AARRVLRGEIVNSIAIAGVLAVHAVTTGFAQPRPLDTEWIDRPTAFAARR
3D structure
PDB1mqw Structure and mechanism of MT-ADPRase, a Nudix hydrolase from Mycobacterium tuberculosis
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R64 A76 E93 E97 E142
Catalytic site (residue number reindexed from 1) R60 A72 E89 E93 E138
Enzyme Commision number 3.6.1.13: ADP-ribose diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A A76 E97 A72 E93
BS02 MN A E93 E97 E142 E89 E93 E138
BS03 ADV A I19 R64 A76 G77 L78 E93 H140 E142 I15 R60 A72 G73 L74 E89 H136 E138
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006753 nucleoside phosphate metabolic process
GO:0019693 ribose phosphate metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1mqw, PDBe:1mqw, PDBj:1mqw
PDBsum1mqw
PubMed12906832
UniProtO33199

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