Structure of PDB 1mqh Chain A

Receptor sequence
>1mqhA (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEALEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKN
KWWYDKGECG
3D structure
PDB1mqh Structural basis for partial agonist action at ionotropic glutamate receptors
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BWD A Y61 L90 T91 R96 G141 S142 T143 L192 E193 M196 Y59 L88 T89 R94 G139 S140 T141 L190 E191 M194 MOAD: ic50=0.3uM
PDBbind-CN: -logKd/Ki=6.52,IC50=0.30uM
BindingDB: Ki=61nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1mqh, PDBe:1mqh, PDBj:1mqh
PDBsum1mqh
PubMed12872125
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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