Structure of PDB 1mqg Chain A

Receptor sequence
>1mqgA (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNK
WWYDKGECG
3D structure
PDB1mqg Structural basis for partial agonist action at ionotropic glutamate receptors
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IWD A Y61 L90 T91 R96 G141 S142 T143 E193 M196 Y58 L87 T88 R93 G138 S139 T140 E190 M193 MOAD: ic50=0.52uM
PDBbind-CN: -logKd/Ki=6.28,IC50=0.52uM
BindingDB: Ki=105nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1mqg, PDBe:1mqg, PDBj:1mqg
PDBsum1mqg
PubMed12872125
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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