Structure of PDB 1mq5 Chain A

Receptor sequence
>1mq5A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY
VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT
GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK
3D structure
PDB1mq5 Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D88 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D70 N72 Q75 E76 E77 E80 D56 N58 Q61 E62 E63 E66
BS02 XLC A K96 E97 Y99 R143 E146 F174 D189 A190 V213 W215 G216 E217 G218 C220 G226 I227 Y228 K82 E83 Y85 R132 E135 F162 D179 A180 V203 W205 G206 E207 G208 C209 G216 I217 Y218 MOAD: Ki=1nM
PDBbind-CN: -logKd/Ki=9.00,Ki=1nM
BindingDB: Ki=0.76nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1mq5, PDBe:1mq5, PDBj:1mq5
PDBsum1mq5
PubMed12501180
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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