Structure of PDB 1mm6 Chain A

Receptor sequence
>1mm6A (length=261) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY
KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVID
FSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK
IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIE
QRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLK
NKWWYDKGECG
3D structure
PDB1mm6 Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QUS A Y61 T91 R96 L138 G141 S142 T143 L192 E193 Y60 T90 R95 L137 G140 S141 T142 L191 E192 MOAD: ic50=20nM
PDBbind-CN: -logKd/Ki=7.70,IC50=20nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1mm6, PDBe:1mm6, PDBj:1mm6
PDBsum1mm6
PubMed12501192
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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