Structure of PDB 1ml6 Chain A

Receptor sequence
>1ml6A (length=220) Species: 10090 (Mus musculus) [Search protein sequence]
GKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKLKKDGNLMF
DQVPMVEIDGMKLVQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDL
TEMIGQLVLCPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNR
LTRVDVHLLELLLYVEELDASLLTPFPLLKAFKSRISSLPNVKKFLQPGS
QRKPPLDAKQIEEARKVFKF
3D structure
PDB1ml6 Residues 207, 216, and 221 and the catalytic activity of mGSTA1-1 and mGSTA2-2 toward benzo[a]pyrene-(7R,8S)-diol-(9S,10R)-epoxide
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBX A Y8 F9 R14 K44 Q53 V54 Q66 T67 L110 L207 F221 Y7 F8 R13 K43 Q52 V53 Q65 T66 L109 L206 F220
BS02 GBX A D100 R130 D99 R129
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009617 response to bacterium
GO:0035634 response to stilbenoid
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1ml6, PDBe:1ml6, PDBj:1ml6
PDBsum1ml6
PubMed12549910
UniProtP10648|GSTA2_MOUSE Glutathione S-transferase A2 (Gene Name=Gsta2)

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