Structure of PDB 1mg5 Chain A

Receptor sequence
>1mg5A (length=255) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
SFTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELK
AINPKVTVTFYPYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGILDDHQ
IERTIAVNYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVP
VYSGTKAAVVNFTSSLAKLAPITGVTAYTVNPGITRTTLVHKFNSWLDVE
PQVAEKLLAHPTQPSLACAENFVKAIELNQNGAIWKLDLGTLEAIQWTKH
WDSGI
3D structure
PDB1mg5 Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis
ChainA
Resolution1.63 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N108 S139 Y152 K156
Catalytic site (residue number reindexed from 1) N108 S139 Y152 K156
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACT A S139 Y152 S139 Y152
BS02 NAI A A13 G16 G17 I18 D38 R39 I40 D64 V65 G92 A93 G94 I137 S139 K156 P182 I184 T185 T187 L189 A13 G16 G17 I18 D38 R39 I40 D64 V65 G92 A93 G94 I137 S139 K156 P182 I184 T185 T187 L189
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008774 acetaldehyde dehydrogenase (acetylating) activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006066 alcohol metabolic process
GO:0006067 ethanol metabolic process
GO:0006117 acetaldehyde metabolic process
GO:0006734 NADH metabolic process
GO:0019431 acetyl-CoA biosynthetic process from ethanol
GO:0046164 alcohol catabolic process
GO:0048149 behavioral response to ethanol
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1mg5, PDBe:1mg5, PDBj:1mg5
PDBsum1mg5
PubMed15581900
UniProtP00334|ADH_DROME Alcohol dehydrogenase (Gene Name=Adh)

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