Structure of PDB 1mf1 Chain A

Receptor sequence
>1mf1A (length=430) Species: 10090 (Mus musculus) [Search protein sequence]
ATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDG
KEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKR
LIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAAR
TGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAER
IRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCTV
GGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGH
EWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGI
SYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQ
SYVRFVENHMGVAVKWVGVGKSRESMIQLF
3D structure
PDB1mf1 Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D43 K46 G70 H71 N256
Catalytic site (residue number reindexed from 1) D16 K19 G43 H44 N229
Enzyme Commision number 6.3.4.4: adenylosuccinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A D43 N68 G161 T162 T163 N256 L260 V270 T271 V305 D16 N41 G134 T135 T136 N229 L233 V243 T244 V278
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004019 adenylosuccinate synthase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006167 AMP biosynthetic process
GO:0044208 'de novo' AMP biosynthetic process
GO:0044209 AMP salvage
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mf1, PDBe:1mf1, PDBj:1mf1
PDBsum1mf1
PubMed12186864
UniProtP28650|PURA1_MOUSE Adenylosuccinate synthetase isozyme 1 (Gene Name=Adss1)

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