Structure of PDB 1mem Chain A

Receptor sequence
>1memA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB1mem Crystal structure of human cathepsin K complexed with a potent inhibitor.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H159 N175
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0D6 A Q19 G23 C25 D61 G64 G65 G66 Y67 L157 N158 H159 W177 Q19 G23 C25 D61 G64 G65 G66 Y67 L160 N161 H162 W184 PDBbind-CN: -logKd/Ki=7.94,Ki=11.5nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1mem, PDBe:1mem, PDBj:1mem
PDBsum1mem
PubMed9033587
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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