Structure of PDB 1mai Chain A

Receptor sequence
>1maiA (length=119) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRS
PESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLI
APSPADAQHWVQGLRKIIH
3D structure
PDB1mai Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3P A K30 K32 W36 R40 S55 R56 K57 K19 K21 W25 R29 S44 R45 K46 MOAD: Kd=210nM
PDBbind-CN: -logKd/Ki=6.68,Kd=210nM
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:1mai, PDBe:1mai, PDBj:1mai
PDBsum1mai
PubMed8521504
UniProtP10688|PLCD1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (Gene Name=Plcd1)

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