Structure of PDB 1m8w Chain A

Receptor sequence

>1m8wA (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]

GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKY

3D structure

PDB

1m8w MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	N899 Y900 R936 Q939 H972 Q975 C1007 R1008 Q1011 N1043 Y1044 Q1047 F1077 S1079 N1080 E1083 Y1120 N1122 Y1123 Q1126 Y1156 H1159	N72 Y73 R109 Q112 H145 Q148 C180 R181 Q184 N216 Y217 Q220 F250 S252 N253 E256 Y293 N295 Y296 Q299 Y329 H332	PDBbind-CN: Kd=500nM
BS02	rna	A	Y900 Q903 R936 Q939 H972 R1008 Y1041 N1043 Y1044 Q1047 F1077 S1079 N1080 E1083 Y1120 N1122 Y1123 Q1126 Y1156 H1159	Y73 Q76 R109 Q112 H145 R181 Y214 N216 Y217 Q220 F250 S252 N253 E256 Y293 N295 Y296 Q299 Y329 H332	PDBbind-CN: Kd=500nM

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

View graph for
Molecular Function

External links

PDB	RCSB:1m8w, PDBe:1m8w, PDBj:1m8w
PDBsum	1m8w
PubMed	12202039
UniProt	Q14671\|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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