Structure of PDB 1m74 Chain A

Receptor sequence
>1m74A (length=802) Species: 1423 (Bacillus subtilis) [Search protein sequence]
MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHKTIEFKE
RLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEM
KTGEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGL
TVGLNLNSMSKDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRP
LHFAVIDEVDSILIDEARTPLIISGQAAKSTKLYVQANAFVRTLKAEKDY
TYDIKTKAVQLTEEGMTKAEKAFGIDNLFDVKHVALNHHINQALKAHVAM
QKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLHQAIEAKEGLEIQNESM
TLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTIPTNRPVVR
DDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK
NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVK
ELGGLAVVGTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFG
AERTMAMLDRFGMDDSTPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYD
DVLRQQREVIYKQRFEVIDSENLREIVENMIKSSLERAIAAYTPREELPE
EWKLDGLVDLINTTYLDEGALEKSDIFGKEPDEMLELIMDRIITKYNEKE
EQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHLRAYAQTNPLR
EYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQPQ
EG
3D structure
PDB1m74 Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.4.2.8: protein-secreting ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A M79 F80 P81 F82 Q85 G103 G105 K106 T107 L108 D492 M79 F80 P81 F82 Q85 G103 G105 K106 T107 L108 D492 PDBbind-CN: -logKd/Ki=7.00,Kd=100nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008564 protein-exporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006605 protein targeting
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0017038 protein import
GO:0043952 protein transport by the Sec complex
GO:0065002 intracellular protein transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031522 cell envelope Sec protein transport complex
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1m74, PDBe:1m74, PDBj:1m74
PDBsum1m74
PubMed12242434
UniProtP28366|SECA_BACSU Protein translocase subunit SecA (Gene Name=secA)

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