Structure of PDB 1m72 Chain A

Receptor sequence
>1m72A (length=247) Species: 7108 (Spodoptera frugiperda) [Search protein sequence]
RVARMPVDRNAPYYNMNHKHRGMAIIFNHEHFDIHSLKSRTGTNVDSDNL
SKVLKTLGFKVTVFPNLKSEEINKFIQQTAEMDHSDADCLLVAVLTHGEL
GMLYAKDTHYKPDNLWYYFTADKCPTLAGKPKLFFIQACQGDRLDGGITL
SRSYRIPVHADFLIAFSTVPGYFSWRNTTRGSWFMQALCEELRYAGTERD
ILTLLTFVCQKVALDFESNAPDSAMMHQQKQVPCITSMLTRLLVFGK
3D structure
PDB1m72 Crystal structure of an invertebrate caspase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K77 S78 H136 G137 C178 Q179
Catalytic site (residue number reindexed from 1) K38 S39 H97 G98 C139 Q140
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K77 R79 H136 Q176 C178 F221 S222 W223 R224 N225 T226 S266 N267 K38 R40 H97 Q137 C139 F173 S174 W175 R176 N177 T178 S218 N219
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1m72, PDBe:1m72, PDBj:1m72
PDBsum1m72
PubMed14645217
UniProtP89116|CASP1_SPOFR Caspase-1

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