Structure of PDB 1m6p Chain A

Receptor sequence
>1m6pA (length=146) Species: 9913 (Bos taurus) [Search protein sequence]
EKTCDLVGEKGKESEKELALLKRLTPLFQKSFESTMYSYVFRVCREAGQH
SSGAGLVQIQKSNGKETVVGRFNETQIFQGSNWIMLIYKGGDEYDNHCGR
EQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS
3D structure
PDB1m6p Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D103 R111 D95 R103
BS02 M6P A Y45 Q66 D103 N104 H105 R111 E133 R135 Y143 Y37 Q58 D95 N96 H97 R103 E125 R127 Y135 MOAD: Kd=8uM
PDBbind-CN: -logKd/Ki=5.10,Kd=8uM
Gene Ontology
Molecular Function
GO:0019904 protein domain specific binding
Biological Process
GO:0006622 protein targeting to lysosome
Cellular Component
GO:0005768 endosome
GO:0005794 Golgi apparatus

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Cellular Component
External links
PDB RCSB:1m6p, PDBe:1m6p, PDBj:1m6p
PDBsum1m6p
PubMed9604938
UniProtP11456|MPRD_BOVIN Cation-dependent mannose-6-phosphate receptor (Gene Name=M6PR)

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