Structure of PDB 1m6d Chain A

Receptor sequence
>1m6dA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
APPEWDWRSKGAVTKVKDQGMCGSCWAFSVTGNVEGQWFLNQGTLLSLSE
QELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCQFSA
EKAKVYIQDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL
RPLCSPWLIDHAVLLVGYGQRSDVPFWAIKNSWGTDWGEKGYYYLHRGSG
ACGVNTMASSAVVD
3D structure
PDB1m6d The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H159 N175
Catalytic site (residue number reindexed from 1) Q19 C25 H161 N181
Enzyme Commision number 3.4.22.41: cathepsin F.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYP A Q19 G23 C25 M64 G65 G66 L67 I157 D158 H159 W177 Q19 G23 C25 M64 G65 G66 L67 I159 D160 H161 W183
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1m6d, PDBe:1m6d, PDBj:1m6d
PDBsum1m6d
PubMed12225749
UniProtQ9UBX1|CATF_HUMAN Cathepsin F (Gene Name=CTSF)

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