Structure of PDB 1m64 Chain A

Receptor sequence

>1m64A (length=568) Species: 56812 (Shewanella frigidimarina) [Search protein sequence]

ADNLAEFHVQNQECDSCHTPDGELSNDSLTYENTQCVSCHGTLAEVAETT
KHEHYNAHASHFPGEVACTSCHSAHEKSMVYCDSCHSFDFNMPYAKKWLR
DEPTIAELAKDKSERQAALASAPHDTVDVVVVGSGGAGFSAAISATDSGA
KVILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMKGG
QNINDPALVKVLSSHSKDSVDWMTAMGADLTDVGMMGGASVNRAHRPTGG
AGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLKDDKGTVKGILVKGMYKG
YYWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAE
NAGGALKDMQYIFAHPTLSVKGGVMVTEAVRGNGAILVNREGKRFVNEIT
TRDKASAAILAQTGKSAYLIFDDSVRKSLSKIDKYIGLGVAPTADSLVKL
GKMEGIDGKALTETVARYNSLVSSGKDTDFERPNLPRALNEGNYYAIEVT
PGVHHTMGGVMIDTKAEVMNAKKQVIPGLYGAGEVTGGVHGANRLGGNAI
SDIITFGRLAGEEAAKYS

3D structure

PDB

1m64 Engineering water to act as an active site acid catalyst in a soluble fumarate reductase

Chain

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	M236 F363 H365 M375 E378 R381 R402 H504 H505 R544
Catalytic site (residue number reindexed from 1)	M236 F363 H365 M375 E378 R381 R402 H504 H505 R544
Enzyme Commision number	1.3.2.4: fumarate reductase (cytochrome).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	V9 C14 C17 H18 L24 S73 A74 H75	V9 C14 C17 H18 L24 S73 A74 H75
BS02	HEM	A	L4 H8 Q12 C36 C39 H40 H72 Y94	L4 H8 Q12 C36 C39 H40 H72 Y94
BS03	HEM	A	H40 L43 H52 A57 H58 C68 C71 H72 F90 N91 M92	H40 L43 H52 A57 H58 C68 C71 H72 F90 N91 M92
BS04	HEM	A	S60 H61 F62 C82 C85 H86 F88 V374 K431 Y435 L438	S60 H61 F62 C82 C85 H86 F88 V374 K431 Y435 L438
BS05	FAD	A	V132 G135 A137 E156 K157 G163 N164 A165 L167 A168 A169 G170 G171 R277 G278 T313 Q338 D344 M375 H504 H505 G533 E534 G547 A549 I550 I553	V132 G135 A137 E156 K157 G163 N164 A165 L167 A168 A169 G170 G171 R277 G278 T313 Q338 D344 M375 H504 H505 G533 E534 G547 A549 I550 I553
BS06	FUM	A	G170 M375 T377 E378 R544 G546	G170 M375 T377 E378 R544 G546

Gene Ontology

	Molecular Function
GO:0009055	electron transfer activity
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0008202	steroid metabolic process
GO:0009061	anaerobic respiration
GO:0019645	anaerobic electron transport chain

	Cellular Component
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1m64, PDBe:1m64, PDBj:1m64
PDBsum	1m64
PubMed	12356299
UniProt	P0C278\|FCCA_SHEFR Fumarate reductase (cytochrome) (Gene Name=fccA)

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