Structure of PDB 1m5w Chain A

Receptor sequence
>1m5wA (length=242) Species: 562 (Escherichia coli) [Search protein sequence]
AELLLGVNIDHIATLRNARGTAYPDPVQAAFIAEQAGADGITVHLREDRR
HITDRDVRILRQTLDTRMNLEMAVTEEMLAIAVETKPHFCCLVPEKRQEV
TTEGGLDVAGQRDKMRDACKRLADAGIQVSLFIDADEEQIKAAAEVGAPF
IEIHTGCYADAKTDAEQAQELARIAKAATFAASLGLKVNAGHGLTYHNVK
AIAAIPEMHELNIGHAIIGRAVMTGLKDAVAEMKRLMLEARG
3D structure
PDB1m5w Multistate Binding in Pyridoxine 5'-Phosphate Synthase: 1.96 A Crystal Structure in Complex with 1-deoxy-D-xylulose phosphate
ChainA
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N9 H12 H45 R47 R51 E72 T103 E153 H193
Catalytic site (residue number reindexed from 1) N8 H11 H44 R46 R50 E71 T102 E152 H192
Enzyme Commision number 2.6.99.2: pyridoxine 5'-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXP A D11 H12 R47 E72 T102 T103 H193 D10 H11 R46 E71 T101 T102 H192 MOAD: Kd=54uM
PDBbind-CN: -logKd/Ki=4.27,Kd=54uM
BS02 PO4 A H193 G194 I214 G215 H216 H192 G193 I213 G214 H215
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016769 transferase activity, transferring nitrogenous groups
GO:0033856 pyridoxine 5'-phosphate synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0008615 pyridoxine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1m5w, PDBe:1m5w, PDBj:1m5w
PDBsum1m5w
PubMed12269807
UniProtP0A794|PDXJ_ECOLI Pyridoxine 5'-phosphate synthase (Gene Name=pdxJ)

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