Structure of PDB 1m54 Chain A

Receptor sequence

>1m54A (length=352) Species: 9606 (Homo sapiens)

DAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIG
KKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT
SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNPE
SHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDML
VASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTY
EVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAG
STVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEED
LT

3D structure

• PDB: 1m54 HUMAN CYSTATHIONINE BETA-SYNTHASE IS A HEME SENSOR PROTEIN. EVIDENCE THAT THE REDOX SENSOR IS HEME AND NOT THE VICINAL CYSTEINES IN THE CXXC MOTIF SEEN IN THE CRYSTAL STRUCTURE OF THE TRUNCATED ENZYME
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K119 S147 D281 S285 L287 S349 P375
• Catalytic site (residue number reindexed from 1): K73 S101 D230 S234 L236 S298 P324
• Enzyme Commision number: 4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	K119 N149 V255 G256 T257 G259 T260 G305 S349 P375 D376	K73 N103 V204 G205 T206 G208 T209 G254 S298 P324 D325
BS02	HEM	A	R51 C52 T53 W54 R58 E62 S63 P64 H65 A226 P229 L230 Y233 R266	R5 C6 T7 W8 R12 E16 S17 P18 H19 A175 P178 L179 Y182 R215

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0019343 cysteine biosynthetic process via cystathionine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1m54, PDBe:1m54, PDBj:1m54
• PDBsum: 1m54
• PubMed: 12173932
• UniProt: P35520|CBS_HUMAN Cystathionine beta-synthase (Gene Name=CBS)