Structure of PDB 1m4m Chain A

Receptor sequence
>1m4mA (length=112) Species: 10090 (Mus musculus) [Search protein sequence]
PQIWQLYLKNYRIATFKNWPFLEDCACTPERMAEAGFIHCPTENEPDLAQ
CFFCFKELEGWEPDDNPIEEHRKHSPGCAFLTVKKQMEELTVSEFLKLDR
QRAKNKIAKETN
3D structure
PDB1m4m CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E76 H80 E70 H74
BS02 ZN A C57 C60 H77 C84 C51 C54 H71 C78
Gene Ontology
Molecular Function
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
GO:0042803 protein homodimerization activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 metal ion binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000281 mitotic cytokinesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007094 mitotic spindle assembly checkpoint signaling
GO:0007127 meiosis I
GO:0007346 regulation of mitotic cell cycle
GO:0010466 negative regulation of peptidase activity
GO:0031503 protein-containing complex localization
GO:0031536 positive regulation of exit from mitosis
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0045931 positive regulation of mitotic cell cycle
GO:0051256 mitotic spindle midzone assembly
GO:0051301 cell division
GO:0051303 establishment of chromosome localization
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469 regulation of type B pancreatic cell proliferation
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:1901970 positive regulation of mitotic sister chromatid separation
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490 positive regulation of mitotic cytokinesis
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0015630 microtubule cytoskeleton
GO:0030496 midbody
GO:0031021 interphase microtubule organizing center
GO:0032133 chromosome passenger complex
GO:1990713 survivin complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1m4m, PDBe:1m4m, PDBj:1m4m
PDBsum1m4m
PubMed10949038
UniProtO70201|BIRC5_MOUSE Baculoviral IAP repeat-containing protein 5 (Gene Name=Birc5)

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