Structure of PDB 1m4i Chain A

Receptor sequence
>1m4iA (length=181) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHA
LIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALL
DAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTP
DDDGTVFVLPIDISLDTSAELMCDWRAGDVW
3D structure
PDB1m4i Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A F32 V84 A85 V86 R91 G92 R94 V96 Y126 F32 V84 A85 V86 R91 G92 R94 V96 Y126
BS02 KAN A D35 F36 D40 E82 S117 D152 W181 D35 F36 D40 E82 S117 D152 W181
BS03 PAP A H54 H55 D89 W90 Q93 H54 H55 D89 W90 Q93
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0034069 aminoglycoside N-acetyltransferase activity
GO:0047921 aminoglycoside 2'-N-acetyltransferase activity
Biological Process
GO:0030649 aminoglycoside antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:1m4i, PDBe:1m4i, PDBj:1m4i
PDBsum1m4i
PubMed12161746
UniProtP9WQG9|AAC2_MYCTU Aminoglycoside 2'-N-acetyltransferase (Gene Name=aac)

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