Structure of PDB 1m2z Chain A

Receptor sequence
>1m2zA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVI
AAVKWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLC
FAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLL
SSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL
DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKL
LFHQK
3D structure
PDB1m2z Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 M593 E755 N759 V53 K57 L67 M71 E233 N237
BS02 DEX A M560 N564 G567 Q570 M601 M604 F623 Q642 C736 M38 N42 G45 Q48 M79 M82 F101 Q120 C214 BindingDB: EC50=2.5nM,Ki=1.2nM,IC50=5nM,Kd=19nM
External links
PDB RCSB:1m2z, PDBe:1m2z, PDBj:1m2z
PDBsum1m2z
PubMed12151000
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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