Structure of PDB 1m13 Chain A

Receptor sequence
>1m13A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVKWSQVRKDLCSLKV
SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI
SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDT
AGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRV
VDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL
LRIQDIHPFATPLMQELFGITGS
3D structure
PDB1m13 2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HYF A L209 M243 S247 F281 C284 Q285 F288 W299 M323 H407 I414 L48 M82 S86 F120 C123 Q124 F127 W138 M162 H246 I253 MOAD: Kd=27nM
PDBbind-CN: -logKd/Ki=7.57,Kd=27nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1m13, PDBe:1m13, PDBj:1m13
PDBsum1m13
PubMed12578355
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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