Structure of PDB 1m0u Chain A

Receptor sequence
>1m0uA (length=203) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
KHSYTLFYFNVKALAEPLRYLFAYGNQEYEDVRVTRDEWPALKPTMPMGQ
MPVLEVDGKRVHQSISMARFLAKTVGLCGATPWEDLQIDIVVDTINDFRL
KIAVVSYEPEDEIKEKKLVTLNAEVIPFYLEKLEQTVKDNDGHLALGKLT
WADVYFAGITDYMNYMVKRDLLEPYPALRGVVDAVNALEPIKAWIEKRPV
TEV
3D structure
PDB1m0u Structure of a Drosophila Sigma Class Glutathione S-transferase Reveals a Novel Active Site Topography Suited for Lipid Peroxidation Products
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y54 L60 R65
Catalytic site (residue number reindexed from 1) Y8 L14 R19
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A Y54 F55 L60 W85 Q96 M97 S110 Y8 F9 L14 W39 Q50 M51 S64
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0004667 prostaglandin-D synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0009636 response to toxic substance
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1m0u, PDBe:1m0u, PDBj:1m0u
PDBsum1m0u
PubMed12547198
UniProtP41043|GSTS1_DROME Glutathione S-transferase S1 (Gene Name=GstS1)

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