Structure of PDB 1lxm Chain A

Receptor sequence
>1lxmA (length=794) Species: 1311 (Streptococcus agalactiae) [Search protein sequence]
HPQPVTTQIEKSVNTALNKNYVFNKADYQYTLTNPSLGKIVGGILYPNAT
GSTTVKISDKSGKIIKEVPLSVTASTEDNFTKLLDKWNDVTIGNYVYDTN
DSNMQKLNQKLDETNAKNIEAIKLDSNRTFLWKDLDNLNNSAQLTATYRR
LEDLAKQITNPHSTIYKNEKAIRTVKESLAWLHQNFYNVNKDIEGSANWW
DFEIGVPRSITGTLSLMNNYFTDAEIKTYTDPIEHFVPDAEYFRKTLVNP
FKALGGNLVDMGRVKIIEGLLRKDNTIIEKTSHSLKNLFTTATKAEGFYA
DGSYIDHTNVAYTGAYGNVLIDGLTQLLPIIQETDYKISNQELDMVYKWI
NQSFLPLIVKGELMDMSRGRSISREAASSHAAAVEVLRGFLRLANMSNEE
RNLDLKSTIKTIITSNKFYNVFNNLKSYSDIANMNKLLNDSTVATKPLKS
NLSTFNSMDRLAYYNAKKDFGFALSLHSKRTLNYEGMNDENTRGWYTGDG
MFYIYNSDQSHYSNHFWPTVNPYKMAGTTEKDAKREDTTKEAKEKTGQVT
GTSDFVGSVKLNDHFALAAMDFTNWDRTLTAQKGWVILNDKIVFLGSNIK
NTNGIGNVSTTIDQRKDDSKTPYTTYVNGKTISQQFTDTKSVFLESKEPG
RNIGYIFFKNSTIDIERKEQTGTWNSINRTSKNTSIVSNPFITISQKHDS
YGYMMVPNIDRTSFDKLANSKEVELLENSSKQQVIYDKNSQTWAVIKHDN
QESLINNQFKMNKAGLYLVQKVGNDYQNVYYQPQTMTKTDQLAI
3D structure
PDB1lxm Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N429 H479 Y488 R542 E657
Catalytic site (residue number reindexed from 1) N257 H307 Y316 R370 E485
Enzyme Commision number 4.2.2.1: hyaluronate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BDP A W372 R380 W200 R208
BS02 BDP A R560 N596 K598 R388 N424 K426
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lxm, PDBe:1lxm, PDBj:1lxm
PDBsum1lxm
PubMed12130645
UniProtQ53591|HYSA_STRA3 Hyaluronate lyase (Gene Name=hylB)

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