Structure of PDB 1lwi Chain A

Receptor sequence
>1lwiA (length=305) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MDSISLRVALNDGNFIPVLGFGTTVPAKDEVIKATKIAIDNGFRHFDSAY
LYEVEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTL
KSTQLDYVDLYIIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEK
CKDAGLAKSIGVSNFNCRQLERILNKPGLKYKPVCNQVECHLYLNQSKML
DYCKSKDIILVSYCTLGSKTWVDQKSPVLLDDPVLCAIAKKYKQTPALVA
LRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN
NAKYF
3D structure
PDB1lwi Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D50 Y55 K84 H117
Catalytic site (residue number reindexed from 1) D47 Y52 K81 H114
Enzyme Commision number 1.1.1.50: 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G22 T24 D50 Y55 H117 Q190 Y216 C217 L219 S221 A253 R270 S271 R276 G22 T24 D47 Y52 H114 Q187 Y213 C214 L216 S218 A247 R264 S265 R270
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0016229 steroid dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0032052 bile acid binding
GO:0047023 androsterone dehydrogenase activity
GO:0047042 androsterone dehydrogenase (B-specific) activity
GO:0047086 ketosteroid monooxygenase activity
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0008202 steroid metabolic process
GO:0021766 hippocampus development
GO:0042448 progesterone metabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lwi, PDBe:1lwi, PDBj:1lwi
PDBsum1lwi
PubMed8718859
UniProtP23457|DIDH_RAT 3-alpha-hydroxysteroid dehydrogenase (Gene Name=Akr1c9)

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