Structure of PDB 1lw7 Chain A

Receptor sequence
>1lw7A (length=344) Species: 727 (Haemophilus influenzae) [Search protein sequence]
EKKVGVIFGKFYPVHTGHINMIYEAFSKVDELHVIVCSDTVRDLKLFYDS
KMKRMPTVQDRLRWMQQIFKYQKNQIFIHHLVEDGIPSYPNGWQSWSEAV
KTLFHEKHFEPSIVFSSEPQDKAPYEKYLGLEVSLVDPDRTFFNVSATKI
RTTPFQYWKFIPKEARPFFAKTVAILGGESSGKSVLVNKLAAVFNTTSAW
EYGREFVFEKLGGDEQAMQYSDYPQMALGHQRYIDYAVRHSHKIAFIDTD
FITTQAFCIQYEGKAHPFLDSMIKEYPFDVTILLKNNTEQKQRQQFQQLL
KKLLDKYKVPYIEIESPSYLDRYNQVKAVIEKVLNEEEISELQN
3D structure
PDB1lw7 Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities.
ChainA
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.22: ribosylnicotinamide kinase.
2.7.7.1: nicotinamide-nucleotide adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A F64 G65 K66 H71 H74 R98 E139 P143 Y145 G148 W149 W152 S172 S173 E174 R196 F8 G9 K10 H15 H18 R42 E83 P87 Y89 G92 W93 W96 S116 S117 E118 R140
BS02 NAD A S254 A255 W256 Y289 Y292 S198 A199 W200 Y233 Y236
Gene Ontology
Molecular Function
GO:0000309 nicotinamide-nucleotide adenylyltransferase activity
GO:0003824 catalytic activity
GO:0050262 ribosylnicotinamide kinase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009435 NAD biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1lw7, PDBe:1lw7, PDBj:1lw7
PDBsum1lw7
PubMed12068016
UniProtP44308|NADR_HAEIN Bifunctional NAD biosynthesis protein NadR (Gene Name=nadR)

[Back to BioLiP]