Structure of PDB 1lv5 Chain A

Receptor sequence

>1lv5A (length=580) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]

AKMAFTLADRVTEEMLADKAALVVEVVEENYHAAPIVGIAVVNEHGRFFL
RPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLL
AAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEH
LVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVD
TKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPV
LKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVR
PDTKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESD
WLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDE
VTPNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGV
KRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPI
QGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCR
LVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

3D structure

PDB

1lv5 Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	P531 T552 T556 R578 K582 Y587 R615 Q624 N625 I626 P627 I628 R629 H829	P235 T256 T260 R282 K286 Y291 R319 Q328 N329 I330 P331 I332 R333 H533
BS02	dna	A	N529 S585 T586 T611 S617 S618 T619 E620 N622 G711 Y714 I716 S717 R771 N782 F786 R789 M790 N793 Q797	N233 S289 T290 T315 S321 S322 T323 E324 N326 G415 Y418 I420 S421 R475 N486 F490 R493 M494 N497 Q501
BS03	MN	A	D653 Y654 D830	D357 Y358 D534
BS04	DCP	A	R615 D653 Y654 Q656 E658 H682 R702 K706 F710 D830	R319 D357 Y358 Q360 E362 H386 R406 K410 F414 D534

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0008408	3'-5' exonuclease activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1lv5, PDBe:1lv5, PDBj:1lv5
PDBsum	1lv5
PubMed	12649320
UniProt	P52026\|DPO1_GEOSE DNA polymerase I (Gene Name=polA)

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