Structure of PDB 1lt8 Chain A

Receptor sequence
>1lt8A (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
KGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKGQEVNEAAADIARQVADEGDALVAGGVS
QTPSYLSAKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVET
LIASGKPVAATMAIGPEGDLHGVPPGEAAVRLVKAGASIIGVNCHFDPTI
SLKTVKLMKEGLEAAQLKAHLMSQPLAYHTPDANKQGFIDLPEFPFGLEP
RVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPP
ASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPD
3D structure
PDB1lt8 Betaine-homocysteine methyltransferase: zinc in a distorted barrel.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.5: betaine--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C217 C300 C194 C277
BS02 CBH A G28 F29 V30 W44 F76 E159 Y160 C217 I262 F267 C299 C300 G18 F19 V20 W34 F66 E136 Y137 C194 I239 F244 C276 C277 BindingDB: Kd=280nM,Ki=12nM,IC50=87nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0047150 betaine-homocysteine S-methyltransferase activity
Biological Process
GO:0006479 protein methylation
GO:0006577 amino-acid betaine metabolic process
GO:0006579 amino-acid betaine catabolic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0046500 S-adenosylmethionine metabolic process
GO:0050666 regulation of homocysteine metabolic process
GO:0071266 'de novo' L-methionine biosynthetic process
GO:0071267 L-methionine salvage
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lt8, PDBe:1lt8, PDBj:1lt8
PDBsum1lt8
PubMed12220488
UniProtQ93088|BHMT1_HUMAN Betaine--homocysteine S-methyltransferase 1 (Gene Name=BHMT)

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