Structure of PDB 1ls5 Chain A

Receptor sequence
>1ls5A (length=328) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
SENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSI
GCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPY
KFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKID
NALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIH
FGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCD
NDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFI
LGDPFMRKYFTVFDYEKESVGFAVAKNL
3D structure
PDB1ls5 Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D34 S37 N39 W41 Y77 D214 T217
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D34 G36 S76 Y77 G78 S79 I123 Y192 D214 G216 T217 S218 I294 D34 G36 S76 Y77 G78 S79 I123 Y192 D214 G216 T217 S218 I294
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ls5, PDBe:1ls5, PDBj:1ls5
PDBsum1ls5
PubMed12614616
UniProtQ8IM16|PLM4_PLAF7 Plasmepsin IV (Gene Name=PMIV)

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