Structure of PDB 1lpd Chain A

Receptor sequence
>1lpdA (length=254) Species: 3570 (Dianthus caryophyllus) [Search protein sequence]
ATAYTLNLANPSASQYSSFLDQIRNNVRDTSLIYGGTDVEVIGAPSTTDK
FLRLNFQGPRGTVSLGLRRENLYVVAYLAMDNANVNRAYYFKNQITSAEL
TALFPEVVVANQKQLEYGEDYQAIEKNAKITTGDQSRKELGLGINLLITM
IDGVNKKVRVVKDEARFLLIAIQMTAEAARFRYIQNLVTKNFPNKFDSEN
KVIQFQVSWSKISTAIFGDCKNGVFNKDYDFGFGKVRQAKDLQMGLLKYL
GRPK
3D structure
PDB1lpd High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E177 R180
Catalytic site (residue number reindexed from 1) E177 R180
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A Y73 V74 E119 I172 R180 Y73 V74 E119 I172 R180
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030598 rRNA N-glycosylase activity
GO:0090729 toxin activity
Biological Process
GO:0006952 defense response
GO:0017148 negative regulation of translation
GO:0035821 modulation of process of another organism
GO:0050688 regulation of defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:1lpd, PDBe:1lpd, PDBj:1lpd
PDBsum1lpd
PubMed15553110
UniProtP24476|RIP0_DIACA Ribosome-inactivating protein dianthin-30

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