Structure of PDB 1lol Chain A

Receptor sequence
>1lolA (length=204) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACL
NVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTR
PERLSRLREIIGQDSFLISPGGETLRFADAIIVGRSIYLADNPAAAAAGI
IESI
3D structure
PDB1lol Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BU2 A D70 K72 V155 D60 K62 V145
BS02 XMP A A18 D20 K42 S127 S158 P180 G202 R203 A8 D10 K32 S117 S148 P170 G184 R185 MOAD: Ki=0.41uM
PDBbind-CN: -logKd/Ki=6.39,Ki=0.41uM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:1lol, PDBe:1lol, PDBj:1lol
PDBsum1lol
PubMed12011084
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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