Structure of PDB 1lml Chain A

Receptor sequence
>1lmlA (length=465) Species: 5664 (Leishmania major) [Search protein sequence]
VVRDVNWGALRIAVSTEDLTDPAYHCARVGQHVKDHAGAIVTCTAEDILT
NEKRDILVKHLIPQAVQLHTERLKVQQVQGKWKVTDMVGDICGDFKVPQA
HITEGFSNTDFVMYVASVPSEEGVLAWATTCQTFSDGHPAVGVINIPAAN
IASRYDQLVTRVVTHEMAHALGFSGPFFEDARIVANVPNVRGKNFDVPVI
NSSTAVAKAREQYGCDTLEYLEVEDQGGAGSAGSHIKMRNAQDELMAPAA
AAGYYTALTMAIFQDLGFYQADFSKAEVMPWGQNAGCAFLTNKCMEQSVT
QWPAMFCNAIRCPTSRLSLGACGVTRHPGLPPYWQYFTDPSLAGVSAFMD
YCPVVVPYSDGSCTQRASEAHASLLPFNVFSDAARCIDGAFRPKASYAGL
CANVQCDTATRTYSVQVHGSNDYTNCTPGLRVELSTVSNAFEGGGYITCP
PYVEVCQGNVQAAKD
3D structure
PDB1lml The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63).
ChainA
Resolution1.86 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H264 E265 H268 H334
Catalytic site (residue number reindexed from 1) H165 E166 H169 H235
Enzyme Commision number 3.4.24.36: leishmanolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H264 H268 H334 H165 H169 H235
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lml, PDBe:1lml, PDBj:1lml
PDBsum1lml
PubMed9739094
UniProtP08148|GP63_LEIMA Leishmanolysin (Gene Name=gp63)

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