Structure of PDB 1lhu Chain A

Receptor sequence
>1lhuA (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
PAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPK
DDWFMLGLRDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVL
LEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALDG
CLRRDSWLDKQAEISASAPTSLRSC
3D structure
PDB1lhu Steroid Ligands Bind Human Sex Hormone-binding Globulin in Specific Orientations and Produce Distinct Changes in Protein Conformation
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D50 E52 A160 D37 E39 A147
BS02 EST A S42 G58 D65 F67 V105 M107 K134 I141 S29 G45 D52 F54 V92 M94 K121 I128 PDBbind-CN: -logKd/Ki=8.83,Kd=1.48nM
BindingDB: IC50=50nM,Kd=1.5nM
External links
PDB RCSB:1lhu, PDBe:1lhu, PDBj:1lhu
PDBsum1lhu
PubMed12065592
UniProtP04278|SHBG_HUMAN Sex hormone-binding globulin (Gene Name=SHBG)

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