Structure of PDB 1lfo Chain A

Receptor sequence
>1lfoA (length=127) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MNFSGKYQVQSQENFEPFMKAMGLPEDLIQKGKDIKGVSEIVHEGKKVKL
TITYGSKVIHNEFTLGEECELETMTGEKVKAVVKMEGDNKMVTTFKGIKS
VTEFNGDTITNTMTLGDIVYKRVSKRI
3D structure
PDB1lfo The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OLA A K31 G55 S56 K57 K31 G55 S56 K57 MOAD: Kd~2uM
PDBbind-CN: -logKd/Ki=6.70,Kd~0.2uM
BindingDB: Ki=2900nM
BS02 OLA A S39 M74 T102 S39 M74 T102 MOAD: Kd~2uM
PDBbind-CN: -logKd/Ki=6.70,Kd~0.2uM
BindingDB: Ki=2900nM
BS03 BEO A N14 F15 E16 N14 F15 E16
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005324 long-chain fatty acid transmembrane transporter activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0016209 antioxidant activity
GO:0032052 bile acid binding
GO:0051978 lysophospholipid:sodium symporter activity
GO:0070538 oleic acid binding
GO:1901363 heterocyclic compound binding
Biological Process
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0033552 response to vitamin B3
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050892 intestinal absorption
GO:0051977 lysophospholipid transport
GO:0070301 cellular response to hydrogen peroxide
GO:0071456 cellular response to hypoxia
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0045179 apical cortex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lfo, PDBe:1lfo, PDBj:1lfo
PDBsum1lfo
PubMed9054409
UniProtP02692|FABPL_RAT Fatty acid-binding protein, liver (Gene Name=Fabp1)

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