Structure of PDB 1lf3 Chain A

Receptor sequence
>1lf3A (length=331) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
LGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCT
TAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSL
PYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNK
IENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLD
AHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTL
CNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPT
FILGDPFMRKYFTVFDYDNHSVGIALAKKNL
3D structure
PDB1lf3 Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D36 S39 N41 W43 Y79 D216 T219
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EH5 A D34 G36 Y77 V78 S79 Y192 D214 G216 S218 F294 D36 G38 Y79 V80 S81 Y194 D216 G218 S220 F296 PDBbind-CN: -logKd/Ki=7.00,Ki=100nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1lf3, PDBe:1lf3, PDBj:1lf3
PDBsum1lf3
PubMed12614616
UniProtP46925|PLM2_PLAFX Plasmepsin II (Gene Name=PMII)

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