Structure of PDB 1lee Chain A

Receptor sequence
>1leeA (length=331) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
LGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCT
TAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSL
PYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNK
IENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLD
AHVGNISLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTL
CNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPT
FILGDPFMRKYFTVFDYDNHSVGIALAKKNL
3D structure
PDB1lee Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 S37 N39 W41 Y77 D214 T217
Catalytic site (residue number reindexed from 1) D36 S39 N41 W43 Y79 D216 T219
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R36 A D34 G36 N76 Y77 V78 S79 F111 I123 L131 Y192 D214 G216 T217 I290 I300 D36 G38 N78 Y79 V80 S81 F113 I125 L133 Y194 D216 G218 T219 I292 I302 PDBbind-CN: -logKd/Ki=7.74,Ki=18nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1lee, PDBe:1lee, PDBj:1lee
PDBsum1lee
PubMed12454457
UniProtP46925|PLM2_PLAFX Plasmepsin II (Gene Name=PMII)

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